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Genetic epidemiological studies have provided us with strong evidences on genetic contribution to the susceptibility to schizophrenia to date. Nonetheless, the complexed transmission-mode in schizophrenia has been giving limited and equivocal data on the candidate chromosomal region through linkage analysis (LA), despite of its advanced and complicated methodology.
In comparison to LA, association study (AS) is relatively simple and giving more power, given the rapid progression of genotyping on the polymorphic variants with larger scale (e.g., SNPs: single nucleotide polymorphism). Further, AS prompt researchers to set up the list of candidate gene based on the potential relevance to the pathophysiology of the disease. Ultimately, AS pursue the
pharmacogenomic strategy with the goal of identifying genes that influence clinical response to biological therapy, yielding individualized treatment and new drug targets.
The author therefore turns up the role and methodological issues of AS in terms of genetic research on schizophrenia. (Schizophrenia
Clinics 2003;6:3-11) |
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