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Schiztoypal personality disorder (SPD) occurs in up to 3% of the population, and these subjects are phenomenologically and perhaps genotypically related to schizophrenia. The diagnosis of SPD was empirically derived based on the symptoms of individuals with a genetic relationship to schizophrenia patients and SPD may be a more common phenotypic expression of a schizophrenia-related diathesis than schizophrenia itself. In this article, some of the recent research in the structural and functional neuroanatomy, neurochemistry, cognitive function, and psychophysiological study of SPD is reviewed. And the similarity and differences between SPD and schizophrenia and the theoretical implication of these findings are briefly discussed. (Schizophrenia Clinics 2003;6:83-89) |
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