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Antipsychotic-induced hyperprolactinemia can cause various side effects. Because antipsychotics inhibit dopamine receptor which plays a critical role in prolactin release, antipsychotics may cause gynecomastia, galactorrhea, menstrual disturbances, sexual disturbances, decreased bone marrow density, and breast cancer. Most typical antipsychotics and some atypical antipsychotics are considered as prolactin-raising antipsychotics, and other atypical antipsychotics (clozapine, quetiapine, et al) as prolactin-sparing antipsychotics. Clinicians should be familiar with the evaluation and management of hyperprolactinemia, and the compliance of patients about drug can be raised by appropriate intervention and treatment. (Schizophrenia Clinics 2004;7:65-72) |
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