Original article

Korean Journal of Schizophrenia Research 2007;10(1):53-61.

Risperidone과 Olanzapine을 복용 중인 여성 정신분열병 환자에서 인지기능, 프로락틴, 에스트로겐의 비교 및 상관

Ja-Seob Koo, MD1, Seung-Hee Won, MD, PhD1 and Kyung-Phil Kwak, MD2

Abstract

Objectives:This study aimed to examine the effects of risperidone and olanzapine on cognitive functions and prolactin, estrogen levels in women schizophrenia.
Methods:In naturalistic cross-sectional study, 29 schizophrenic outpatient women (under 45 years) who were medicated on same antipsychotics for at least 1 year were enrolled. Serum prolactin, estrogen levels were measured in the mid-luteal phase of the menstrual cycle, the neuropsychological and neurocognitive (Rey-Kim memory test, verbal fluency test, digit span test, Wisconsin card sorting test) batteries were also assessed at the same day.
Results:The risperidone group presented significant higher mean prolactin and lower mean estrogen levels than the olanzapine group. The olanzapine group showed significant higher verbal fluency scores than the risperidone group. Prolactin levels were presented significant negative correlation with scores of total memory test, auditory learning memory test and visual learning memory test. There were positive correlation between estrogen levels and score of digit span test.
Conclusion:The risperidone group showed higher prolactin and lower estrogen levels and less beneficial effects on verbal fluency of cognitive functions than the olanzapine group in female patients with chronic schizophrenia. These results suggest that prolactin and estrogen levels may have direct and indirect effects on some domain of cognitive functions and also provide possible evidences for an association between antipsychotic medication and cognitive functions. Further investigations are required to draw any conclusion. (Korean J Schizophr Res 2007;10:53-61)

Key Words: Schizophrenia,Risperidone,Olanzapine,Prolactin,Estrogen,Cognitive function