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Korean Journal of Schizophrenia Research 2008;11(1):20-25.
정신분열병의 기능적 뇌 영상 연구
Kyung-Min Park, MD and Jae-Jin Kim, MD, PhD
Abstract
Functional magnetic resonance imaging and positron emission tomography studies have demonstrated brain regions associated with clinical symptom, cognition, emotion and social cognition in schizophrenia. The aim of this review is to summarize the various findings of functional brain imaging studies in schizophrenia. Disorganization and psychomotor poverty symptoms are associated with reduced prefrontal activations;auditory hallucinations with increased left superior and middle temporal activations; formal thought disorder with decreased left posterior superior temporal activations;attentions with decreased anterior cingulate cortex;memory with decreased hippocampal complex activations;working memory with decreased lateral prefrontal activations; executive functions with decreased prefrontal activations;emotional face processing with decreased amygdala activations;Theory of Mind with decreased medial prefrontal cortex. However, these findings should be considered in the context of disconnection syndrome in schizophrenia. (Korean J Schizophr Res 2008;11:20-25)
Key Words: Schizophrenia,Functional imaging,fMRI,PET
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