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Korean Journal of Schizophrenia Research 2008;11(1):26-30.
정신분열병 환자에서의 강박증상에 관한 연구:발생 빈도, 임상 특성 및 삶의 질
Myung Ji Lee, MD1, Ji Suk Jun, MD2, Yong Bum Shin, MD2, Min Hee Kang, MD2, Jeong Seop Lee, MD2, Jae Nam Bae, MD2 and Chul Eung Kim, MD2
Objectives:Obsessive-compulsive disorder (OCD) have been observed in a substantial proportion of schizophrenia. This study aimed to evaluate the prevalence of obsessive-compulsive disorder in schizophrenia, and the relationship between obsessivecompulsive disorder and severity of psychopathology, depressive symptoms and quality of life in schizophrenia.
Methods:We interviewed 87 patients, diagnosed as schizophrenia and classified patients according to the existence of OCD evaluated by the Structured Clinical Interview for DSM-Ⅳ. And we evaluated the clinical and demographic data. To investigate the interrelationship, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Positive and Negative Symptom Scale (PANSS), Hamilton rating scale for Depression (HRSD), World Health Organization Quality of life-Brief Scale (WHOQOL-BREF) were applied. Independent t-test, Chi-square test were used to compare groups and Pearson’s correlation was used to assess the relationship between Y-BOCS and other clinical rating scales.
Results:The prevalence of OCD in schizophrenia patients was 16.1%. Patients with schizophrenia and obsessive-compulsive disorder had earlier age at onset and higher mean PANSS-general psychopathology and total score than schizophrenia patients without obsessive-compulsive disorder. The compulsive act sub-score of Y-BOCS was significantly correlated with PANSSpositive score in patients with schizophrenia.
Conclusion:OCD is relatively frequent in schizophrenia patients and significantly correlated with the severity of psychotic symptoms. (Korean J Schizophr Res 2008;11:26-30)
Key Words: Obsessive-compulsive disorder,Schizophrenia,Psychopathology,Depression,Quality of life
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