Original article

Korean Journal of Schizophrenia Research 2010;13(2):116-123.

정신분열병 환자에서 대사성 증후군 발생과 관련된 사회인구학적 특성과 임상적 요인：1년간의 전향적 추적연구

Eek-Hee Yang, MD1, Nam Hee Kim, MD1, Jae-Yeol Jeong, MD1 and Min-Jeong Kwak, PhD2

Abstract

Objectives:Metabolic syndrome is prevalent among patients with schizophrenia, yet there has been no prospective study on the correlation between this diagnosis and illness severity. This study aimed to investigate the incidence of metabolic syndrome in a one-year follow-up of schizophrenia patients and its association with clinical variables, including Positive and Negative Syndrome Scale (PANSS) scores.
Methods:Of 112 baseline patients enrolled, 74 completed the 12-month study. We defined metabolic syndrome and determined its incidence per the American Heart Association (AHA)/ National Heart, Lung, and Blood Institute (NHLBI) criteria. We measured socio-demographic, psychiatric, and metabolic profile differences between those with and without metabolic syndrome via unpaired t-tests or chi-square tests. We also conducted logistic regression tests to find variables that best described the development of metabolic syndrome.
Results:Within one year, 20 patients (27%) developed metabolic syndrome. The odds ratio between sleep duration and metabolic syndrome was 2.03. Fasting blood sugar and central obesity highly predicted the risk of metabolic syndrome. PANSS scores on the negative subscale were higher in patients with metabolic syndrome.
Conclusion:This is the first prospective study to investigate the correlation between PANSS and metabolic syndrome. Assessment of the associated risks of metabolic syndrome should be included in the clinical management of schizophrenia patients, to enhance the long-term treatment outcomes. (Korean J Schizophr Res 2010;13:116-123)

Key Words: Metabolic syndrome,Antipsychotics,Schizophrenia,Obesity,Dyslipidemia,Positive and negative syndrome scale.