Association between Antipsychotic-Related Restless Legs Syndrome and the RORA Gene Polymorphism in Schizophrenia.

Jung, Jin Sook; Cho, Chul Hyun; Yoon, Ho Kyoung; Kang, Seung Gul; Park, Young Min; Lee, Heon Jeong; Kim, Leen

doi:2013.16.2.93

Korean J Schizophr Res > Volume 16(2); 2013 > Article

Original Article

Korean Journal of Schizophrenia Research 2013;16(2):93-97.
DOI: https://doi.org/10.16946/kjsr.2013.16.2.93 Published online October 31, 2013.

Association between Antipsychotic-Related Restless Legs Syndrome and the RORA Gene Polymorphism in Schizophrenia.

Jin Sook Jung, Chul Hyun Cho, Ho Kyoung Yoon, Seung Gul Kang, Young Min Park, Heon Jeong Lee, Leen Kim

¹Department of Psychiatry, Korea University College of Medicine, Seoul, Korea. leehjeong@korea.ac.kr
²Department of Psychiatry, Gil Medical Center, Gachon Medical School, Incheon, Korea.
³Department of Psychiatry, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.

Abstract

OBJECTIVES
The previous studies have suggested genetic vulnerability to restless legs syndrome (RLS) development. The occurrence of antipsychotic-related RLS could also be attributable to differences in genetic susceptibility. This study aimed to investigate whether Retinoid-related orphan receptor A (RORA) gene polymorphism is associated with antipsychotic-related RLS in schizophrenia.
METHODS
We assessed symptoms of antipsychotic-induced RLS in 190 Korean schizophrenic patients and divided the subjects into two groups according to the International Restless Legs Syndrome Study Group diagnostic criteria : 1) subjects that met all of the criteria (n=44) and 2) the remaining subjects who were not considered to be RLS patients (n=146). Single-nucleotide polymorphism in the RORA gene was genotyped by PCR in 190 individuals. The chi2-test was conducted to compare differences between two groups.
RESULTS
The frequencies of genotype (chi2=0.066, p=0.968) of the RORA gene (rs11071547) did not differ significantly between schizophrenic patients with and without RLS. The difference of allele frequencies (chi2=0.008, p=0.927) of the RORA gene (rs 11071547) between the schizophrenic patients with and without RLS were not significant.
CONCLUSION
These results suggest that RORA gene polymorphism does not play a major role in susceptibility to antipsychotic-related RLS in schizophrenia.

Key Words: RLS · Schizophrenia · RORA · Genetic polymorphism · Circadian rhythm