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Korean J Schizophr Res > Volume 15(1); 2012 > Article
Korean Journal of Schizophrenia Research 2012;15(1):34-38.
DOI: https://doi.org/10.16946/kjsr.2012.15.1.34    Published online June 30, 2012.
Association Study between Tryptophan Hydroxylase 2 Gene -703G/T Polymorphism and Tardive Dyskinesia.
Jong Hun Lee, Seung Gul Kang, Young Min Park, Heon Jeong Lee, Seog Ju Kim, Leen Kim
1Department of Psychiatry, Catholic University of Daegu, College of Medicine, Daegu, Korea.
2Department of Psychiatry, Gachon University School of Medicine, Incheon, Korea.
3Department of Psychiatry, Inje University College of Medicine, Goyang, Korea.
4Department of Psychiatry, Korea University College of Medicine, Seoul, Korea. leehjeong@korea.ac.kr
5Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.
Tardive dyskinesia (TD) is a serious and sometimes irreversible adverse effect that may develop during long-term antipsychotics treatment. Previous studies have suggested that brain serotonergic systems are related to TD vulnerability and tryptophan hydroxylase (TPH) is the rate limiting enzyme in the biosynthesis of serotonin. This study aimed to investigate the association between TPH2 gene -703G/T polymorphism (rs4570625) and antipsychotic-induced TD in the Korean schizophrenia patients.
We investigated whether TPH2 gene -703G/T polymorphism is associated with antipsychotic-induced TD in 280 Korean schizophrenia patients. The subjects with TD (n=105) and without TD (n=175) were matched for antipsychotic drug exposure and other relevant variables.
There was no significant difference in the distribution of genotypic (chi2=3.00, p=0.223) and allelic (chi2=0.19, p=0.661) frequencies between patients group with TD and without TD. There was no significant difference in total Abnormal Involuntary Movement Scale score (F=1.95, p=0.362) among the genotype groups, either.
The present study does not support that TPH2 gene -703G/T polymorphism is involved in TD of the Korean schizophrenia subjects.
Key Words: Tardive dyskinesia · Tryptophan hydroxylase 2 gene · Schizophrenia


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