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Korean J Schizophr Res > Volume 20(1); 2017 > Article
Korean Journal of Schizophrenia Research 2017;20(1):15-22.
DOI: https://doi.org/10.16946/kjsr.2017.20.1.15    Published online April 30, 2017.
Predicting Prognosis in Patients with First Episode Psychosis Using Mismatch Negativity : A 1 Year Follow-up Study.
Moonyoung Jang, Minah Kim, Tak Hyung Lee, Jun Soo Kwon
1Seoul National University College of Medicine, Seoul, Korea.
2Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. verte82@snu.ac.kr
3Department of Brain and Cognitive Science-World Class University Program, Seoul National University College of Natural Science, Seoul, Korea.
It has been shown that early intervention is crucial for favorable outcome in patients with schizophrenia. However, development of biomarkers for predicting prognosis of psychotic disorder still requires more research. In this study, we aimed to investigate whether baseline mismatch negativity (MMN) predict prognosis in patients with first episode psychosis (FEP).
Twenty-four patients with FEP and matched healthy controls (HCs) were examined with MMN at baseline, and their clinical status were re-assessed after 1 year. Repeated-measures analysis of variance was performed to compare baseline MMN between the two groups. Multiple regression analysis was used to identify factors predicting prognosis in FEP patients during the follow-up period.
MMN amplitudes at baseline were significantly reduced in patients with FEP compared to healthy controls. In the multiple regression analysis, baseline MMN amplitude significantly predicted later improvement of performances on digit span and delayed recall of California Verbal Learning Test. However, baseline MMN did not predicted improvement of clinical symptoms.
These results indicate that MMN may be a possible predictor of improvement in cognitive functioning in patients with FEP. Future study with larger sample and longer follow-up period would be needed to confirm the findings of the current study.
Key Words: Event related potential · Mismatch negativity · First episode psychosis · Schizophrenia · Cognitive function · Prognosis
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